Greg - to be honest, it doesn't help whatsoever.
Does the radio work, as in light up and let you hear a hiss when you turn down the squelch.
What exactly have you programmed in that doesn't work? What I mean is what frequencies have you entered into the radio? With these, the chances of the radio being faulty are very, very slim - the usual problem is that out of the box they don't do anything until you enter some frequencies. Have you?
Tell us step by step what you have done, what is appearing in the display, and most importantly - where are you? Pointless entering marine band frequencies if you live hundreds of miles from the sea!
ps You have bought one of the most complicated radios that really needs programming with a computer. You bought the lead and software, I assume? Programming anything useful via the keyboard takes a VERY long time and many things are impossible. You should get analogue up and running quickly, but in the supplied version, the digital possibilities are quite limited.